Research workbench
The structure of the mature HIV-1 ca hexameric lattice with curvature parameters: TILT=5, TWIST=0
Analyse The structure of the mature HIV-1 ca hexameric lattice with curvature… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MD1
- Type
- protein
- Length
- 1,474 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein P24
- UniProt
- A0A0K0V8J8, E9MJT0
- Pockets
- 14 · best druggability 0.36
Structure
electron microscopy · 2 distinct chains · 60% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, F, W, C, D, E, G | Capsid protein P24 | protein | 74 | 64% helix, 0% strand | A0A0K0V8J8 |
| a, b, f, H, I, J | Capsid protein P24 | protein | 147 | 58% helix, 4% strand | E9MJT0 |
Pockets
14 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.36 | 0.72 | 33 | empty |
| 2 | 130 | 0.36 | 0.73 | 28 | empty |
| 3 | 127 | 0.35 | 0.73 | 28 | empty |
| 4 | 94 | 0.30 | 0.72 | 29 | empty |
| 5 | 96 | 0.30 | 0.72 | 23 | empty |
Interfaces
15 interfaces between chains.
- A–a · 66 Ų buried · 2 hydrogen bonds · protein-protein
- C–H · 66 Ų buried · 2 hydrogen bonds · protein-protein
- F–f · 64 Ų buried · 1 hydrogen bond · protein-protein
- E–J · 63 Ų buried · 1 hydrogen bond · protein-protein
- B–b · 56 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5MD1 · The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=5… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0K0V8J8
- Every structure of UniProt E9MJT0
- Elsewhere: RCSB PDB 5MD1 · PDBe 5MD1 · UniProt A0A0K0V8J8 · UniProt E9MJT0
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