Research workbench
Radiation damage to GH7 family cellobiohydrolase from daphnia pulex: dose (dwd) 9.75 mgy
Analyse Radiation damage to GH7 family cellobiohydrolase from daphnia pulex: dose (dwd)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MCH
- Type
- protein
- Length
- 883 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellobiohydrolase chbi
- EC
- 3.2.1.91
- UniProt
- E9G5J5
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellobiohydrolase chbi (EC 3.2.1.91) | protein | 442 | 14% helix, 35% strand | E9G5J5 |
| B | Cellobiohydrolase chbi (EC 3.2.1.91) | protein | 441 | 14% helix, 35% strand | E9G5J5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 926 | 0.82 | 0.84 | 89 | GOL |
| 2 | 855 | 0.82 | 0.84 | 75 | GOL |
| 3 | 560 | 0.65 | 0.76 | 60 | empty |
| 4 | 100 | 0.36 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 221 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 18 disulfide, 2 modified (disulfide, cyclization).
Compared structures
- 5MCH · Radiation damage to GH7 Family Cellobiohydrolase from Daphnia pulex: Dose (DWD) 9.75 MGy · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9G5J5
- Elsewhere: RCSB PDB 5MCH · PDBe 5MCH · UniProt E9G5J5
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