Research workbench

Interactions between the MAL3 EB1-like domain and DIS1

Analyse Interactions between the MAL3 EB1-like domain and DIS1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5M9E
Type: protein
Length: 342 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule integrity protein MAL3; Phosphoprotein P93
UniProt: Q10113, Q09933
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 8 distinct chains · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Microtubule integrity protein MAL3	protein	69	84% helix, 0% strand	Q10113
B	Microtubule integrity protein MAL3	protein	71	82% helix, 0% strand	Q10113
C	Microtubule integrity protein MAL3	protein	68	88% helix, 0% strand	Q10113
D	Microtubule integrity protein MAL3	protein	70	83% helix, 0% strand	Q10113
E	Phosphoprotein P93	protein	19	0% helix, 11% strand	Q09933
F	Phosphoprotein P93	protein	20	0% helix, 10% strand	Q09933
G	Phosphoprotein P93	protein	13	0% helix, 0% strand	Q09933
H	Phosphoprotein P93	protein	12	0% helix, 0% strand	Q09933

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	155	0.45	0.76	27	empty

Interfaces

17 interfaces between chains.

A–B · 1719 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 1622 Å² buried · 4 hydrogen bonds · protein-protein
E–F · 545 Å² buried · 4 hydrogen bonds · protein-protein
D–G · 532 Å² buried · 5 hydrogen bonds · protein-protein
C–F · 497 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5M9E · Interactions between the Mal3 EB1-like domain and Dis1 · the same entry in another collection · chain H against H, TM-score 1.00
Q10113 · AlphaFold monomer V2.0 prediction for microtubule integrity protein MAL3 (Q10113) · a predicted model of the same protein · chain D against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q10113
Every structure of UniProt Q09933
Elsewhere: RCSB PDB 5M9E · PDBe 5M9E · UniProt Q10113 · UniProt Q09933

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