Research workbench
Spliceosome component
Analyse Spliceosome component in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5M89
- Type
- protein
- Length
- 655 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spliceosome WD40 sc
- UniProt
- G0SFY0
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spliceosome WD40 sc | protein | 326 | 11% helix, 53% strand | G0SFY0 |
| B | Spliceosome WD40 sc | protein | 329 | 10% helix, 52% strand | G0SFY0 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 868 | 0.77 | 0.80 | 69 | empty |
| 2 | 882 | 0.77 | 0.80 | 67 | empty |
| 3 | 294 | 0.56 | 0.76 | 42 | empty |
| 4 | 125 | 0.49 | 0.79 | 19 | empty |
| 5 | 88 | 0.42 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 295 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5M89 · Spliceosome component · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SFY0
- Elsewhere: RCSB PDB 5M89 · PDBe 5M89 · UniProt G0SFY0
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