Research workbench
Neutral trehalase NTH1 from saccharomyces cerevisiae in complex with trehalose
Analyse Neutral trehalase NTH1 from saccharomyces cerevisiae in complex with trehalose in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5M4A
- Type
- protein
- Length
- 548 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutral trehalase
- EC
- 3.2.1.28
- UniProt
- P32356
- Ligands
- GLC
- Pockets
- 8 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neutral trehalase (EC 3.2.1.28) | protein | 548 | 50% helix, 10% strand | P32356 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.66 | 0.82 | 25 | GLC |
| 2 | 163 | 0.49 | 0.77 | 21 | empty |
| 3 | 119 | 0.45 | 0.77 | 16 | empty |
| 4 | 60 | 0.41 | 0.81 | 17 | empty |
| 5 | 126 | 0.41 | 0.75 | 24 | empty |
Compared structures
- 5M4A · Neutral trehalase Nth1 from Saccharomyces cerevisiae in complex with trehalose · the same entry in another collection · chain A against A, TM-score 1.00
- P32356 · AlphaFold monomer V2.0 prediction for neutral trehalase (P32356) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32356
- Elsewhere: RCSB PDB 5M4A · PDBe 5M4A · UniProt P32356
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