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Crystal structure of human angiotensin I-deleted angiotensinogen

Analyse Crystal structure of human angiotensin I-deleted angiotensinogen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5M3X
Type: protein
Length: 770 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiotensinogen
UniProt: P01019
Pockets: 6 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Angiotensinogen	protein	383	33% helix, 33% strand	P01019
B	Angiotensinogen	protein	387	33% helix, 33% strand	P01019

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.49	0.75	23	empty
2	170	0.45	0.74	24	empty
3	51	0.42	0.83	13	empty
4	79	0.35	0.75	17	empty
5	69	0.32	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 297 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5M3X · Crystal structure of human angiotensin I-deleted angiotensinogen · the same entry in another collection · chain A against A, TM-score 1.00
P01019 · AlphaFold monomer V2.0 prediction for angiotensinogen (P01019) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01019
Elsewhere: RCSB PDB 5M3X · PDBe 5M3X · UniProt P01019

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