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Molecular basis of mitomycin C resictance in streptomyces: crystal structures of the mrd protein with and without a drug derivative

Analyse Molecular basis of mitomycin C resictance in streptomyces: crystal structures… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KMZ
Type: protein
Length: 125 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitomycin-binding protein
UniProt: O05205
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitomycin-binding protein	protein	125	29% helix, 38% strand	O05205

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	101	0.53	0.83	25	empty

Compared structures

1KMZ · Molecular basis of mitomycin C resictance in streptomyces: crystal structures of the mrd… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O05205
Elsewhere: RCSB PDB 1KMZ · PDBe 1KMZ · UniProt O05205

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