Research workbench

Mamk non-polymerising A278D mutant bound to amppnp

Analyse Mamk non-polymerising A278D mutant bound to amppnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5LJW
Type: protein
Length: 656 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin-like ATPase
UniProt: Q2W8Q6
Ligands: ANP, MG
Pockets: 7 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin-like ATPase	protein	331	41% helix, 24% strand	Q2W8Q6
B	Actin-like ATPase	protein	325	40% helix, 26% strand	Q2W8Q6

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	968	0.76	0.78	92	MG, ANP
2	382	0.61	0.77	49	MG, ANP
3	121	0.46	0.78	18	empty
4	136	0.41	0.75	24	empty
5	75	0.36	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 661 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5LJW · MamK non-polymerising A278D mutant bound to AMPPNP · the same entry in another collection · chain A against A, TM-score 1.00
Q2W8Q6 · AlphaFold monomer V2.0 prediction for actin-like protein mamk (Q2W8Q6) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2W8Q6
Elsewhere: RCSB PDB 5LJW · PDBe 5LJW · UniProt Q2W8Q6

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