Research workbench

The N-terminal WD40 domain of APC1 (anaphase promoting complex subunit 1)

Analyse The N-terminal WD40 domain of APC1 (anaphase promoting complex subunit 1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5LGG
Type: protein
Length: 378 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anaphase-promoting complex subunit 1,ANAPHASE-promoting complex subunit…
UniProt: Q9H1A4
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anaphase-promoting complex subunit 1,ANAPHASE-promoting complex subunit 1,ANAPHASE-promoting complex subunit 1,ANAPHASE- promoting complex subunit 1	protein	378	4% helix, 51% strand	Q9H1A4

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	905	0.69	0.74	61	empty
2	194	0.58	0.81	26	empty
3	208	0.46	0.74	24	empty

Compared structures

5LGG · The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1) · the same entry in another collection · chain A against A, TM-score 1.00
Q9H1A4 · AlphaFold monomer V2.0 prediction for anaphase-promoting complex subunit 1 (Q9H1A4) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H1A4
Elsewhere: RCSB PDB 5LGG · PDBe 5LGG · UniProt Q9H1A4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.