Research workbench
Crystal structure of the bacterial proteasome activator bpa of mycobacterium tuberculosis (space group P3)
Analyse Crystal structure of the bacterial proteasome activator bpa of mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5LFQ
- Type
- protein
- Length
- 1,808 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterial proteasome activator
- UniProt
- P9WKX3
- Pockets
- 20 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | Bacterial proteasome activator | protein | 113 | 75% helix, 2% strand | P9WKX3 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 254 | 0.58 | 0.78 | 36 | empty |
| 2 | 279 | 0.57 | 0.77 | 26 | empty |
| 3 | 224 | 0.56 | 0.78 | 32 | empty |
| 4 | 219 | 0.55 | 0.78 | 25 | empty |
| 5 | 211 | 0.54 | 0.78 | 21 | empty |
Interfaces
27 interfaces between chains.
- G–H · 1153 Ų buried · 16 hydrogen bonds · protein-protein
- O–P · 1153 Ų buried · 13 hydrogen bonds · protein-protein
- I–J · 1150 Ų buried · 12 hydrogen bonds · protein-protein
- B–G · 1140 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1136 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 48 modified (engineered).
Compared structures
- 5LFQ · Crystal Structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis… · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WKX3
- Elsewhere: RCSB PDB 5LFQ · PDBe 5LFQ · UniProt P9WKX3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.