Research workbench
Crystal structure of darpin-darpin rigid fusion, variant DD_D12_09_D12
Analyse Crystal structure of darpin-darpin rigid fusion, variant DD_D12_09_D12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5LE3
- Type
- protein
- Length
- 1,224 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DD_D12_09_D12
- Pockets
- 9 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | DD_D12_09_D12 | protein | 306 | 57% helix, 0% strand | — |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 278 | 0.84 | 0.95 | 30 | empty |
| 2 | 411 | 0.84 | 0.91 | 38 | empty |
| 3 | 293 | 0.59 | 0.78 | 32 | empty |
| 4 | 216 | 0.53 | 0.77 | 25 | empty |
| 5 | 81 | 0.34 | 0.74 | 13 | empty |
Interfaces
3 interfaces between chains.
- B–C · 888 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 881 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 150 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5LE3 · Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_09_D12 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5LE3 · PDBe 5LE3
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