Research workbench
Structure of the large gamma subunit of initiation factor EIF2 from pyrococcus abyssi
Analyse Structure of the large gamma subunit of initiation factor EIF2 from pyrococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KK0
- Type
- protein
- Length
- 399 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- EIF2GAMMA
- UniProt
- Q9V1G0
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | EIF2GAMMA | protein | 399 | 18% helix, 40% strand | Q9V1G0 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.53 | 0.79 | 35 | empty |
| 2 | 215 | 0.50 | 0.76 | 30 | empty |
| 3 | 172 | 0.48 | 0.77 | 25 | empty |
| 4 | 111 | 0.43 | 0.77 | 19 | empty |
| 5 | 91 | 0.42 | 0.78 | 14 | empty |
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 1KK0 · Structure of the large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi · the same entry in another collection · chain A against A, TM-score 1.00
- Q9V1G0 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9V1G0
- Elsewhere: RCSB PDB 1KK0 · PDBe 1KK0 · UniProt Q9V1G0
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