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Structure of the large gamma subunit of initiation factor EIF2 from pyrococcus abyssi-G235D mutant

Analyse Structure of the large gamma subunit of initiation factor EIF2 from pyrococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KJZ
Type: protein
Length: 400 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: EIF2GAMMA
UniProt: Q9V1G0
Ligands: ZN
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	EIF2GAMMA	protein	400	19% helix, 41% strand	Q9V1G0

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.57	0.76	43	empty
2	166	0.55	0.80	36	empty
3	118	0.43	0.77	21	empty
4	89	0.42	0.79	15	empty
5	80	0.34	0.75	15	empty

Compared structures

1KJZ · Structure of the large gamma subunit of initiation factor eIF2 from Pyrococcus… · the same entry in another collection · chain A against A, TM-score 1.00
Q9V1G0 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9V1G0
Elsewhere: RCSB PDB 1KJZ · PDBe 1KJZ · UniProt Q9V1G0

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