Research workbench
The crystal structure of the human SNF5/INI1 domain
Analyse The crystal structure of the human SNF5/INI1 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5L7A
- Type
- protein
- Length
- 265 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B…
- UniProt
- Q12824
- Pockets
- 1 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | protein | 64 | 42% helix, 31% strand | Q12824 |
| C | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | protein | 68 | 49% helix, 29% strand | Q12824 |
| D | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | protein | 69 | 42% helix, 29% strand | Q12824 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1175 | 0.80 | 0.82 | 88 | empty |
Interfaces
5 interfaces between chains.
- B–C · 565 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 559 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 368 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 368 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 167 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5L7A · The crystal structure of the Human SNF5/INI1 domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q12824 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12824
- Elsewhere: RCSB PDB 5L7A · PDBe 5L7A · UniProt Q12824
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