Research workbench
Crystal structure of a human fasl mutant in complex with human DCR3
Analyse Crystal structure of a human fasl mutant in complex with human DCR3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5L36
- Type
- protein
- Length
- 291 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor necrosis factor receptor superfamily member 6B; Tumor necrosis factor ligand…
- UniProt
- O95407, P48023
- Ligands
- NA
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Tumor necrosis factor receptor superfamily member 6B | protein | 153 | 0% helix, 40% strand | O95407 |
| A | Tumor necrosis factor ligand superfamily member 6 | protein | 138 | 2% helix, 55% strand | P48023 |
Ligands and binding sites
- NA · Sodium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.50 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- B–A · 488 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 5L36 · Crystal Structure of a human FasL mutant in complex with human DcR3 · the same entry in another collection · chain B against B, TM-score 1.00
- P48023 · AlphaFold monomer V2.0 prediction for tumor necrosis factor ligand superfamily member 6… · a predicted model of the same protein · chain A against A, TM-score 0.98
- O95407 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95407
- Every structure of UniProt P48023
- Elsewhere: RCSB PDB 5L36 · PDBe 5L36 · UniProt O95407 · UniProt P48023
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