Research workbench
Structure of cntnw N149L in the intermediate 2 state
Analyse Structure of cntnw N149L in the intermediate 2 state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5L24
- Type
- protein
- Length
- 1,227 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoside permease
- UniProt
- G4CRQ5
- Ligands
- 6ZL
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 3 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoside permease | protein | 420 | 74% helix, 0% strand | G4CRQ5 |
| C | Nucleoside permease | protein | 399 | 75% helix, 0% strand | G4CRQ5 |
| B | Nucleoside permease | protein | 408 | 76% helix, 0% strand | G4CRQ5 |
Ligands and binding sites
- 6ZL · 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl) oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · ligand · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 676 | 0.87 | 0.90 | 46 | empty |
| 2 | 495 | 0.78 | 0.85 | 55 | empty |
| 3 | 450 | 0.74 | 0.83 | 43 | empty |
| 4 | 405 | 0.72 | 0.82 | 51 | empty |
| 5 | 50 | 0.67 | 0.96 | 23 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1354 Ų buried · 4 hydrogen bonds · protein-protein
- C–B · 1331 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 1306 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5L24 · Structure of CNTnw N149L in the intermediate 2 state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G4CRQ5
- Elsewhere: RCSB PDB 5L24 · PDBe 5L24 · UniProt G4CRQ5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.