Research workbench
Structure of a complex between S. cerevisiae CSM1 and MAM1
Analyse Structure of a complex between S. cerevisiae CSM1 and MAM1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5KTB
- Type
- protein
- Length
- 351 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monopolin complex subunit CSM1; Monopolin complex subunit MAM1
- UniProt
- P25651, P40065
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 58% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monopolin complex subunit CSM1 | protein | 151 | 60% helix, 23% strand | P25651 |
| B | Monopolin complex subunit CSM1 | protein | 158 | 61% helix, 22% strand | P25651 |
| C | Monopolin complex subunit MAM1 | protein | 42 | 40% helix, 0% strand | P40065 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.52 | 0.80 | 29 | empty |
| 2 | 134 | 0.46 | 0.78 | 23 | empty |
| 3 | 58 | 0.31 | 0.75 | 15 | empty |
| 4 | 51 | 0.29 | 0.74 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2322 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1372 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 243 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5KTB · Structure of a complex between S. cerevisiae Csm1 and Mam1 · the same entry in another collection · chain A against A, TM-score 1.00
- P25651 · AlphaFold monomer V2.0 prediction for monopolin complex subunit CSM1 (P25651) · a predicted model of the same protein · chain B against A, TM-score 0.87
- P40065 · AlphaFold monomer V2.0 prediction for monopolin complex subunit MAM1 (P40065) · a predicted model of the same protein · chain C against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25651
- Every structure of UniProt P40065
- Elsewhere: RCSB PDB 5KTB · PDBe 5KTB · UniProt P25651 · UniProt P40065
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