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Crystal structure of tryptophan synthase subunit alpha from legionella pneumophila str. paris

Analyse Crystal structure of tryptophan synthase subunit alpha from legionella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5KMY
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase alpha chain
EC: 4.2.1.20
UniProt: Q5X5Q1
Pockets: 3 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophan synthase alpha chain (EC 4.2.1.20)	protein	262	52% helix, 13% strand	Q5X5Q1

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	228	0.57	0.78	27	empty
2	82	0.49	0.83	20	empty
3	95	0.43	0.78	17	empty

Modifications

Observed in the structure: 11 modified (engineered).

Compared structures

5KMY · Crystal structure of tryptophan synthase subunit alpha from Legionella pneumophila str.… · the same entry in another collection · chain A against A, TM-score 1.00
Q5X5Q1 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (Q5X5Q1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5X5Q1
Elsewhere: RCSB PDB 5KMY · PDBe 5KMY · UniProt Q5X5Q1

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