Research workbench
Structure of trypanosoma congolense insect stage antigen
Analyse Structure of trypanosoma congolense insect stage antigen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5KMX
- Type
- protein
- Length
- 778 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein TCIL3000_10_9440
- UniProt
- G0UXP9
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.45
Structure
x-ray diffraction · 5 distinct chains · 16% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative uncharacterized protein TCIL3000_10_9440 | protein | 202 | 18% helix, 44% strand | G0UXP9 |
| B | Putative uncharacterized protein TCIL3000_10_9440 | protein | 196 | 17% helix, 45% strand | G0UXP9 |
| C | Putative uncharacterized protein TCIL3000_10_9440 | protein | 182 | 15% helix, 43% strand | G0UXP9 |
| D | Putative uncharacterized protein TCIL3000_10_9440 | protein | 184 | 15% helix, 45% strand | G0UXP9 |
| U | Putative uncharacterized protein TCIL3000_10_9440 | protein | 14 | 0% helix, 7% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 8 copies · chains A, U, D, B, C
- GOL · Glycerol · additive · 2 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.45 | 0.74 | 25 | empty |
| 2 | 71 | 0.33 | 0.76 | 21 | SO4 |
| 3 | 69 | 0.29 | 0.73 | 13 | empty |
| 4 | 56 | 0.24 | 0.71 | 12 | empty |
| 5 | 52 | 0.24 | 0.73 | 11 | empty |
Interfaces
5 interfaces between chains.
- B–C · 856 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 812 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 672 Ų buried · 5 hydrogen bonds · protein-protein
- A–U · 431 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 44 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 5KMX · Structure of Trypanosoma congolense Insect Stage Antigen · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0UXP9
- Elsewhere: RCSB PDB 5KMX · PDBe 5KMX · UniProt G0UXP9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.