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Crystal structure of the drosophila pumilio RNA-binding domain in complex with hunchback RNA

Analyse Crystal structure of the drosophila pumilio RNA-binding domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5KLA
Type: protein + RNA
Length: 345 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maternal protein pumilio; RNA (5'-R(*UP*GP*UP*AP*CP*AP*UP*A)-3')
UniProt: P25822

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Maternal protein pumilio	protein	337	72% helix, 0% strand	P25822
B	RNA (5'-R(UPGPUPAPCPAPUPA)-3')	rna	8	—	—

Ligands and binding sites

ACT · Acetate ion · additive · 3 copies · chains A, B
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 1216 Å² buried · 42 hydrogen bonds · protein-nucleic

Compared structures

5KLA · Crystal structure of the drosophila Pumilio RNA-binding domain in complex with hunchback… · the same entry in another collection · chain A against A, TM-score 1.00
P25822 · AlphaFold monomer V2.0 prediction for maternal protein pumilio (P25822) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25822
Elsewhere: RCSB PDB 5KLA · PDBe 5KLA · UniProt P25822

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