How FAPP2 selects simple glycosphingolipids using the gltp-fold

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 3% strand (DSSP).

Ligands and binding sites

• 6S8 · (~{Z})-~{N}-[(~{E},2~{S},3~{R})-1-[(2~{R},3~{R},4~{S}, 5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl) oxan-2-yl]oxy-3-oxidanyl-octadec-4-en-2-yl]octadec-9-enamide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1096 Ų buried · 7 hydrogen bonds · protein-protein

Compared structures

• 5KDI · How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold · the same entry in another collection · chain A against A, TM-score 1.00
• Q96JA3 · AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing family a… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q96JA3
• Elsewhere: RCSB PDB 5KDI · PDBe 5KDI · UniProt Q96JA3