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Crystal structure of tryptophan synthase alpha chain from legionella pneumophila subsp. pneumophila

Analyse Crystal structure of tryptophan synthase alpha chain from legionella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5K9X
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase alpha chain
EC: 4.2.1.20
UniProt: Q5ZVY3
Pockets: 3 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophan synthase alpha chain (EC 4.2.1.20)	protein	262	52% helix, 13% strand	Q5ZVY3

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.53	0.78	31	empty
2	92	0.52	0.83	22	empty
3	82	0.37	0.76	14	empty

Modifications

Observed in the structure: 11 modified (engineered).

Compared structures

5K9X · Crystal structure of Tryptophan synthase alpha chain from Legionella pneumophila subsp.… · the same entry in another collection · chain A against A, TM-score 1.00
Q5ZVY3 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (Q5ZVY3) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5ZVY3
Elsewhere: RCSB PDB 5K9X · PDBe 5K9X · UniProt Q5ZVY3

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