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Trypanosoma brucei bromodomain BDF5 (TB427TMP.01.5000)

Analyse Trypanosoma brucei bromodomain BDF5 (TB427TMP.01.5000) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5K29
Type: protein
Length: 182 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein BDF5
UniProt: Q382J7
Ligands: UNX
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein BDF5	protein	97	68% helix, 0% strand	Q382J7
B	Uncharacterized protein BDF5	protein	85	65% helix, 0% strand	Q382J7

Ligands and binding sites

UNX · Unknown atom or ion · ion · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.32	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 160 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5K29 · Trypanosoma brucei bromodomain BDF5 (Tb427tmp.01.5000) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q382J7
Elsewhere: RCSB PDB 5K29 · PDBe 5K29 · UniProt Q382J7

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