Research workbench
Crystal structure of cytidine monophosphate hydroxymethylase mila
Analyse Crystal structure of cytidine monophosphate hydroxymethylase mila in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JNH
- Type
- protein
- Length
- 634 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cmp 5-hydroxymethylase
- UniProt
- B4Y380
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cmp 5-hydroxymethylase | protein | 318 | 46% helix, 19% strand | B4Y380 |
| B | Cmp 5-hydroxymethylase | protein | 316 | 46% helix, 19% strand | B4Y380 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 538 | 0.76 | 0.83 | 46 | empty |
| 2 | 556 | 0.74 | 0.81 | 49 | empty |
| 3 | 219 | 0.62 | 0.82 | 34 | empty |
| 4 | 78 | 0.47 | 0.82 | 19 | empty |
| 5 | 93 | 0.44 | 0.79 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 2265 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 5JNH · Crystal Structure of cytidine monophosphate hydroxymethylase MilA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4Y380
- Elsewhere: RCSB PDB 5JNH · PDBe 5JNH · UniProt B4Y380
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