Research workbench

Hsluv complex

Analyse Hsluv complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JI3
Type: protein
Length: 1,424 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent protease subunit hslv; ATP-dependent protease ATPase subunit hslu
EC: 3.4.25.2
UniProt: B7LA29, P0A6H6
Ligands: DAT
Pockets: 13 · best druggability 0.88

Structure

x-ray diffraction · 3 distinct chains · 56% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	ATP-dependent protease subunit hslv (EC 3.4.25.2)	protein	174	39% helix, 31% strand	B7LA29
E	ATP-dependent protease ATPase subunit hslu	protein	375	61% helix, 9% strand	P0A6H6
F	ATP-dependent protease ATPase subunit hslu	protein	353	59% helix, 11% strand	P0A6H6

Ligands and binding sites

DAT · 2'-deoxyadenosine-5'-diphosphate · ligand · 2 copies · chains E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	980	0.88	0.89	106	DAT
2	894	0.74	0.78	98	empty
3	267	0.63	0.81	34	DAT
4	134	0.62	0.86	24	empty
5	122	0.53	0.82	20	empty

Interfaces

8 interfaces between chains.

E–F · 2261 Å² buried · 27 hydrogen bonds · protein-protein
C–D · 790 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 656 Å² buried · 1 hydrogen bond · protein-protein
A–D · 595 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 472 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5JI3 · HslUV complex · the same entry in another collection · chain F against F, TM-score 1.00
B7LA29 · AlphaFold monomer V2.0 prediction for ATP-dependent protease subunit hslv (B7LA29) · a predicted model of the same protein · chain A against A, TM-score 0.98
P0A6H6 · AlphaFold monomer V2.0 prediction for ATP-dependent protease ATPase subunit hslu (P0A6H6) · a predicted model of the same protein · chain F against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B7LA29
Every structure of UniProt P0A6H6
Elsewhere: RCSB PDB 5JI3 · PDBe 5JI3 · UniProt B7LA29 · UniProt P0A6H6

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