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Phosphorylated trif in complex with irf-3

Analyse Phosphorylated trif in complex with irf-3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JEL
Type: protein
Length: 248 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon regulatory factor 3; Phosphorylated trif peptide
UniProt: Q14653
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interferon regulatory factor 3	protein	234	26% helix, 32% strand	Q14653
B	Phosphorylated trif peptide	protein	14	50% helix, 14% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.31	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 658 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 modified (phosphorylation).

Compared structures

5JEL · Phosphorylated TRIF in complex with IRF-3 · the same entry in another collection · chain A against A, TM-score 1.00
Q14653 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 3 (Q14653) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14653
Elsewhere: RCSB PDB 5JEL · PDBe 5JEL · UniProt Q14653

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