Research workbench
X-ray structure of nysgrc target T-45
Analyse X-ray structure of nysgrc target T-45 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KCX
- Type
- protein
- Length
- 952 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydropyrimidinase related protein-1
- UniProt
- P97427
- Pockets
- 9 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Dihydropyrimidinase related protein-1 | protein | 476 | 37% helix, 23% strand | P97427 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.85 | 0.87 | 106 | empty |
| 2 | 174 | 0.60 | 0.82 | 28 | empty |
| 3 | 185 | 0.57 | 0.81 | 30 | empty |
| 4 | 87 | 0.49 | 0.83 | 19 | empty |
| 5 | 92 | 0.46 | 0.80 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1275 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97427
- Elsewhere: RCSB PDB 1KCX · PDBe 1KCX · UniProt P97427
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