Research workbench

ALPHA1-antitrypsin

Analyse ALPHA1-antitrypsin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KCT
Type: protein
Length: 375 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ALPHA1-antitrypsin
UniProt: P01009
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ALPHA1-antitrypsin	protein	375	8% helix, 11% strand	P01009

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.69	0.85	48	empty
2	187	0.68	0.86	28	empty
3	181	0.53	0.78	26	empty
4	89	0.49	0.82	20	empty

Compared structures

1KCT · ALPHA1-antitrypsin · the same entry in another collection · chain A against A, TM-score 1.00
P01009 · AlphaFold monomer V2.0 prediction for alpha-1-antitrypsin (P01009) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01009
Elsewhere: RCSB PDB 1KCT · PDBe 1KCT · UniProt P01009

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