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Crystal structure of antigen-ERAP1 domain complex

Analyse Crystal structure of antigen-ERAP1 domain complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5J5E
Type: protein
Length: 408 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoplasmic reticulum aminopeptidase 1
EC: 3.4.11.-
UniProt: Q9NZ08
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-)	protein	408	59% helix, 10% strand	Q9NZ08

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	359	0.61	0.77	33	empty
2	205	0.50	0.76	15	empty
3	53	0.40	0.81	12	empty

Compared structures

5J5E · crystal structure of antigen-ERAP1 domain complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9NZ08 · AlphaFold monomer V2.0 prediction for endoplasmic reticulum aminopeptidase 1 (Q9NZ08) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZ08
Elsewhere: RCSB PDB 5J5E · PDBe 5J5E · UniProt Q9NZ08

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