Research workbench
Intermediate state lying on the pathway of release of tat from HIV-1 tar.
Analyse Intermediate state lying on the pathway of release of tat from HIV-1 tar. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5J2W
- Type
- protein + RNA
- Length
- 43 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclic peptide mimetic of HIV-1 tat; Apical region (29MER) of the HIV-1 tar RNA element
- Pockets
- 2 · best druggability 0.46
Structure
solution nmr · 2 distinct chains · 0% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclic peptide mimetic of HIV-1 tat | protein | 14 | 0% helix, 57% strand | — |
| B | Apical region (29MER) of the HIV-1 tar RNA element | rna | 29 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.46 | 0.76 | 24 | empty |
| 2 | 82 | 0.38 | 0.78 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 733 Ų buried · 25 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 d-amino (D-amino acid).
Compared structures
- 5J2W · Intermediate state lying on the pathway of release of Tat from HIV-1 TAR. · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5J2W · PDBe 5J2W
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.