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Hcmv DNA polymerase processivity subunit UL44 at neutral pH and low salt

Analyse Hcmv DNA polymerase processivity subunit UL44 at neutral pH and low salt in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IXA
Type: protein
Length: 501 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase processivity factor
UniProt: P16790
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA polymerase processivity factor	protein	250	19% helix, 44% strand	P16790
B	DNA polymerase processivity factor	protein	251	19% helix, 44% strand	P16790

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.55	0.81	28	empty
2	149	0.52	0.80	29	empty
3	100	0.36	0.74	21	empty
4	62	0.28	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 827 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5IXA · HCMV DNA polymerase processivity subunit UL44 at neutral pH and low salt · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16790
Elsewhere: RCSB PDB 5IXA · PDBe 5IXA · UniProt P16790

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