Research workbench
Crystal structure of yeast TSR1, a pre-40S ribosome synthesis factor
Analyse Crystal structure of yeast TSR1, a pre-40S ribosome synthesis factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5IW7
- Type
- protein
- Length
- 2,248 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosome biogenesis protein TSR1,RIBOSOME biogenesis protein TSR1
- UniProt
- Q07381
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 4 distinct chains · 19% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosome biogenesis protein TSR1,RIBOSOME biogenesis protein TSR1 | protein | 595 | 20% helix, 33% strand | Q07381 |
| B | Ribosome biogenesis protein TSR1,RIBOSOME biogenesis protein TSR1 | protein | 569 | 19% helix, 33% strand | Q07381 |
| C | Ribosome biogenesis protein TSR1,RIBOSOME biogenesis protein TSR1 | protein | 567 | 19% helix, 34% strand | Q07381 |
| D | Ribosome biogenesis protein TSR1,RIBOSOME biogenesis protein TSR1 | protein | 517 | 19% helix, 31% strand | Q07381 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1008 | 0.88 | 0.89 | 97 | empty |
| 2 | 161 | 0.76 | 0.93 | 35 | empty |
| 3 | 661 | 0.75 | 0.81 | 78 | empty |
| 4 | 803 | 0.74 | 0.79 | 98 | empty |
| 5 | 814 | 0.74 | 0.78 | 82 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1422 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1072 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1024 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5IW7 · Crystal structure of yeast Tsr1, a pre-40S ribosome synthesis factor · the same entry in another collection · chain D against D, TM-score 1.00
- Q07381 · AlphaFold monomer V2.0 prediction for ribosome biogenesis protein TSR1 (Q07381) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07381
- Elsewhere: RCSB PDB 5IW7 · PDBe 5IW7 · UniProt Q07381
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