Research workbench
Crystal structure of D-sorbitol dehydrogenase in substrate-free form
Analyse Crystal structure of D-sorbitol dehydrogenase in substrate-free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ITG
- Type
- protein
- Length
- 968 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sorbitol dehydrogenase
- UniProt
- Q9KWR5
- Pockets
- 9 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sorbitol dehydrogenase | protein | 484 | 49% helix, 13% strand | Q9KWR5 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 605 | 0.68 | 0.77 | 57 | empty |
| 2 | 441 | 0.64 | 0.77 | 40 | empty |
| 3 | 325 | 0.54 | 0.75 | 35 | empty |
| 4 | 147 | 0.45 | 0.76 | 26 | empty |
| 5 | 108 | 0.35 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 234 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 5ITG · Crystal structure of D-sorbitol dehydrogenase in substrate-free form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KWR5
- Elsewhere: RCSB PDB 5ITG · PDBe 5ITG · UniProt Q9KWR5
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