Research workbench
Structure of reaction loop cleaved lamprey angiotensinogen
Analyse Structure of reaction loop cleaved lamprey angiotensinogen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5INW
- Type
- protein
- Length
- 729 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative angiotensinogen; C-terminal peptide of putative angiotensinogen
- UniProt
- C0MNC6, C0MNC7
- Ligands
- SO4
- Pockets
- 7 · best druggability 0.53
Structure
x-ray diffraction · 4 distinct chains · 31% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative angiotensinogen | protein | 335 | 34% helix, 34% strand | C0MNC6 |
| B | Putative angiotensinogen | protein | 331 | 34% helix, 35% strand | C0MNC6 |
| C | C-terminal peptide of putative angiotensinogen | protein | 31 | 0% helix, 55% strand | C0MNC7 |
| D | C-terminal peptide of putative angiotensinogen | protein | 32 | 0% helix, 53% strand | C0MNC7 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.53 | 0.88 | 21 | empty |
| 2 | 128 | 0.51 | 0.80 | 25 | empty |
| 3 | 122 | 0.50 | 0.80 | 26 | empty |
| 4 | 119 | 0.48 | 0.80 | 19 | empty |
| 5 | 107 | 0.47 | 0.80 | 24 | empty |
Interfaces
3 interfaces between chains.
- B–D · 2407 Ų buried · 41 hydrogen bonds · protein-protein
- A–C · 2379 Ų buried · 37 hydrogen bonds · protein-protein
- A–B · 660 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5INW · Structure of reaction loop cleaved lamprey angiotensinogen · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C0MNC6
- Every structure of UniProt C0MNC7
- Elsewhere: RCSB PDB 5INW · PDBe 5INW · UniProt C0MNC6 · UniProt C0MNC7
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