Research workbench
Structure of CLR2 bound to the CLR1 C-terminus
Analyse Structure of CLR2 bound to the CLR1 C-terminus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5IKJ
- Type
- protein
- Length
- 514 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cryptic loci regulator 2; Cryptic loci regulator protein 1
- UniProt
- O13881, O74808
- Ligands
- ZN, CL
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cryptic loci regulator 2 | protein | 448 | 31% helix, 28% strand | O13881 |
| B | Cryptic loci regulator protein 1 | protein | 66 | 26% helix, 15% strand | O74808 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 574 | 0.73 | 0.81 | 76 | empty |
| 2 | 431 | 0.72 | 0.82 | 74 | empty |
| 3 | 188 | 0.51 | 0.78 | 24 | empty |
| 4 | 90 | 0.36 | 0.75 | 20 | empty |
| 5 | 52 | 0.32 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 3660 Ų buried · 55 hydrogen bonds · protein-protein
Compared structures
- 5IKJ · Structure of Clr2 bound to the Clr1 C-terminus · the same entry in another collection · chain A against A, TM-score 1.00
- O13881 · AlphaFold monomer V2.0 prediction for cryptic loci regulator 2 (O13881) · a predicted model of the same protein · chain A against A, TM-score 0.84
- O74808 · AlphaFold monomer V2.0 prediction for cryptic loci regulator protein 1 (O74808) · a predicted model of the same protein · chain B against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13881
- Every structure of UniProt O74808
- Elsewhere: RCSB PDB 5IKJ · PDBe 5IKJ · UniProt O13881 · UniProt O74808
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