Research workbench
Imidazole glycerol phosphate synthase
Analyse Imidazole glycerol phosphate synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KA9
- Type
- protein
- Length
- 446 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Imidazole glycerol phosphate synthase
- UniProt
- Q7SIC0, Q7SIB9
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Imidazole glycerol phosphate synthase | protein | 195 | 25% helix, 29% strand | Q7SIC0 |
| F | Imidazole glycerol phosphate synthase | protein | 251 | 38% helix, 25% strand | Q7SIB9 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 401 | 0.64 | 0.78 | 49 | empty |
| 2 | 178 | 0.59 | 0.82 | 37 | empty |
| 3 | 101 | 0.47 | 0.81 | 20 | empty |
| 4 | 50 | 0.30 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- H–F · 1400 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1KA9 · Imidazole Glycerol Phosphate Synthase · the same entry in another collection · chain H against H, TM-score 1.00
- Q7SIC0 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hish… · a predicted model of the same protein · chain H against A, TM-score 0.99
- Q7SIB9 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hisf… · a predicted model of the same protein · chain F against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SIC0
- Every structure of UniProt Q7SIB9
- Elsewhere: RCSB PDB 1KA9 · PDBe 1KA9 · UniProt Q7SIC0 · UniProt Q7SIB9
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