Cbp in complex with CPD637 ((R)-4-methyl-6-(1-methyl-3-(1-methyl-1H- pyrazol-4-yl)-1H-indazol-5-yl)-1,3,4,5-tetrahydro-2H-BENZO[B][1, 4]DIAZEPIN-2-one)

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 12% strand (DSSP).

Ligands and binding sites

• 69E · (4R)-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one · ligand · chains A
• ZN · Zinc ion · metal · 3 copies · chains A
• NA · Sodium ion · metal · chains A
• EDO · 1,2-ethanediol · additive · 5 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
• B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 5I8G · CBP in complex with Cpd637 ((R)-4-methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indaz… · the same entry in another collection · chain A against A, TM-score 1.00
• Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q92793
• Elsewhere: RCSB PDB 5I8G · PDBe 5I8G · UniProt Q92793