Research workbench
Crystal structure of human SPLUNC1 disulfide mutant M3 (I76C, V214C)
Analyse Crystal structure of human SPLUNC1 disulfide mutant M3 (I76C, V214C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5I7J
- Type
- protein
- Length
- 396 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bpi fold-containing family a member 1
- UniProt
- Q9NP55
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bpi fold-containing family a member 1 | protein | 196 | 33% helix, 32% strand | Q9NP55 |
| B | Bpi fold-containing family a member 1 | protein | 200 | 38% helix, 31% strand | Q9NP55 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.41 | 0.80 | 15 | empty |
| 2 | 52 | 0.35 | 0.78 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 802 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5I7J · Crystal Structure of Human SPLUNC1 Disulfide Mutant M3 (I76C, V214C) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NP55 · AlphaFold monomer V2.0 prediction for bpi fold-containing family a member 1 (Q9NP55) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NP55
- Elsewhere: RCSB PDB 5I7J · PDBe 5I7J · UniProt Q9NP55
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