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X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter

Analyse X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5I66
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 8B6 antibody, heavy chain; 8B6 antibody, light chain
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	8B6 antibody, heavy chain	protein	218	8% helix, 54% strand	—
B	8B6 antibody, light chain	protein	213	6% helix, 50% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	712	0.66	0.75	67	empty
2	135	0.44	0.76	28	empty
3	91	0.35	0.74	26	empty
4	75	0.33	0.75	18	empty
5	82	0.32	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 1875 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5I66 · X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5I66 · PDBe 5I66

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