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Crystal structure of tyrosinase from bacillus megaterium with configuration a of hydroquinone inhibitor in the active site

Analyse Crystal structure of tyrosinase from bacillus megaterium with configuration a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5I3A
Type: protein
Length: 574 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosinase
UniProt: B2ZB02
Ligands: HQE, ZN
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tyrosinase	protein	287	42% helix, 5% strand	B2ZB02

Ligands and binding sites

HQE · benzene-1,4-diol · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	434	0.72	0.82	79	ZN, HQE
2	82	0.40	0.78	16	empty
3	58	0.35	0.78	18	empty
4	58	0.35	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 1204 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

5I3A · Crystal Structure of tyrosinase from Bacillus megaterium with configuration A of hydroqui… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt B2ZB02
Elsewhere: RCSB PDB 5I3A · PDBe 5I3A · UniProt B2ZB02

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