Research workbench
Crystal structure of topo-97, an N-terminal 97KDA fragment of topoisomerase V
Analyse Crystal structure of topo-97, an N-terminal 97KDA fragment of topoisomerase V in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HM5
- Type
- protein
- Length
- 758 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Topoisomerase V
- UniProt
- Q977W1
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 64% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Topoisomerase V | protein | 758 | 64% helix, 2% strand | Q977W1 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1016 | 0.78 | 0.80 | 91 | empty |
| 2 | 56 | 0.57 | 0.90 | 17 | empty |
| 3 | 160 | 0.51 | 0.78 | 27 | empty |
| 4 | 56 | 0.36 | 0.78 | 19 | empty |
| 5 | 68 | 0.30 | 0.74 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5HM5 · Crystal structure of Topo-97, an N-terminal 97kDa fragment of topoisomerase V · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q977W1
- Elsewhere: RCSB PDB 5HM5 · PDBe 5HM5 · UniProt Q977W1
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