Research workbench
Crystal structure of glycine sarcosine N-methyltransferase from methanohalophilus portucalensis in complex with betaine
Analyse Crystal structure of glycine sarcosine N-methyltransferase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HIJ
- Type
- protein
- Length
- 240 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycine sarcosine N-methyltransferase
- EC
- 2.1.1.156
- UniProt
- F6KV61
- Ligands
- BET
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycine sarcosine N-methyltransferase (EC 2.1.1.156) | protein | 240 | 38% helix, 30% strand | F6KV61 |
Ligands and binding sites
- BET · Trimethyl glycine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 673 | 0.78 | 0.83 | 54 | empty |
| 2 | 68 | 0.53 | 0.86 | 18 | empty |
Compared structures
- 5HIJ · Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F6KV61
- Elsewhere: RCSB PDB 5HIJ · PDBe 5HIJ · UniProt F6KV61
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