Research workbench
Human acidic fibroblast growth factor. 141 amino acid form with amino terminal his tag with HIS93 replaced by gly (H93G).
Analyse Human acidic fibroblast growth factor. 141 amino acid form with amino terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1K5U
- Type
- protein
- Length
- 386 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic fibroblast growth factor
- UniProt
- P05230
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Acidic fibroblast growth factor | protein | 129 | 12% helix, 40% strand | P05230 |
| B | Acidic fibroblast growth factor | protein | 128 | 12% helix, 40% strand | P05230 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.58 | 0.76 | 46 | empty |
| 2 | 50 | 0.36 | 0.80 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–C · 284 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 218 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1K5U · Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1K5U · PDBe 1K5U · UniProt P05230
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