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Structure of salmonella enterica effector protein ssel

Analyse Structure of salmonella enterica effector protein ssel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5HAF
Type: protein
Length: 639 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Deubiquitinase ssel
EC: 3.4.22.-
UniProt: Q8ZNG2
Ligands: K
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Deubiquitinase ssel (EC 3.4.22.-)	protein	312	55% helix, 11% strand	Q8ZNG2
B	Deubiquitinase ssel (EC 3.4.22.-)	protein	327	49% helix, 11% strand	Q8ZNG2

Ligands and binding sites

K · Potassium ion · metal · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	300	0.74	0.86	43	K
2	429	0.70	0.81	43	empty
3	343	0.56	0.75	49	empty
4	156	0.43	0.75	27	empty
5	50	0.34	0.79	14	empty

Interfaces

1 interface between chains.

A–B · 1243 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5HAF · Structure of Salmonella enterica effector protein SseL · the same entry in another collection · chain A against A, TM-score 1.00
Q8ZNG2 · AlphaFold monomer V2.0 prediction for deubiquitinase ssel (Q8ZNG2) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8ZNG2
Elsewhere: RCSB PDB 5HAF · PDBe 5HAF · UniProt Q8ZNG2

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