Crystal structure of the BCL6 btb domain in complex with F1324

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 16% strand (DSSP).

Ligands and binding sites

• SO4 · Sulfate ion · ion · 2 copies · chains A, C, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

5 interfaces between chains.

• A–B · 1654 Ų buried · 14 hydrogen bonds · protein-protein
• A–C · 708 Ų buried · 17 hydrogen bonds · protein-protein
• B–D · 666 Ų buried · 13 hydrogen bonds · protein-protein
• A–D · 426 Ų buried · 3 hydrogen bonds · protein-protein
• B–C · 414 Ų buried · 3 hydrogen bonds · protein-protein

Compared structures

• 5H7G · Crystal structure of the BCL6 BTB domain in complex with F1324 · the same entry in another collection · chain A against A, TM-score 1.00
• P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain B against A, TM-score 0.33

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P41182
• Elsewhere: RCSB PDB 5H7G · PDBe 5H7G · UniProt P41182