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Structure of trehalose synthase

Analyse Structure of trehalose synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5H2T
Type: protein
Length: 4,344 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trehalose synthase
UniProt: D1ABU6
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Trehalose synthase	protein	544	31% helix, 17% strand	D1ABU6
H	Trehalose synthase	protein	536	29% helix, 16% strand	D1ABU6

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	881	0.86	0.87	85	empty
2	912	0.85	0.87	101	empty
3	609	0.85	0.89	75	empty
4	939	0.84	0.86	79	empty
5	345	0.79	0.89	45	empty

Interfaces

14 interfaces between chains.

A–H · 1121 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 1095 Å² buried · 3 hydrogen bonds · protein-protein
F–G · 1070 Å² buried · 3 hydrogen bonds · protein-protein
C–E · 1038 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 784 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5H2T · Structure of trehalose synthase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D1ABU6
Elsewhere: RCSB PDB 5H2T · PDBe 5H2T · UniProt D1ABU6

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