Research workbench
Structure of a novel antibody G196
Analyse Structure of a novel antibody G196 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5H2B
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G196 antibody heavy chain; G196 antibody light chain
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G196 antibody heavy chain | protein | 216 | 6% helix, 52% strand | — |
| B | G196 antibody light chain | protein | 211 | 6% helix, 53% strand | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 671 | 0.65 | 0.75 | 69 | empty |
| 2 | 158 | 0.51 | 0.78 | 23 | empty |
| 3 | 125 | 0.49 | 0.80 | 23 | empty |
| 4 | 98 | 0.38 | 0.76 | 18 | empty |
| 5 | 57 | 0.28 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1759 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5H2B · Structure of a novel antibody G196 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5H2B · PDBe 5H2B
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