Research workbench

C. elegans inx-6 gap junction hemichannel

Analyse C. elegans inx-6 gap junction hemichannel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5H1Q
Type: protein
Length: 2,888 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Innexin-6
UniProt: Q9U3N4
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 55% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Innexin-6	protein	361	55% helix, 5% strand	Q9U3N4

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	982	0.80	0.81	88	empty
2	964	0.79	0.81	102	empty
3	876	0.79	0.81	74	empty
4	840	0.78	0.81	81	empty
5	869	0.78	0.81	87	empty

Interfaces

8 interfaces between chains.

C–D · 2077 Å² buried · 13 hydrogen bonds · protein-protein
F–G · 2068 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 2064 Å² buried · 13 hydrogen bonds · protein-protein
A–H · 2063 Å² buried · 13 hydrogen bonds · protein-protein
E–F · 2061 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

5H1Q · C. elegans INX-6 gap junction hemichannel · the same entry in another collection · chain H against H, TM-score 1.00
Q9U3N4 · AlphaFold monomer V2.0 prediction for innexin-6 (Q9U3N4) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U3N4
Elsewhere: RCSB PDB 5H1Q · PDBe 5H1Q · UniProt Q9U3N4

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