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Crystal structure of apo-CASTOR1

Analyse Crystal structure of apo-CASTOR1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5GT8
Type: protein
Length: 1,080 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gats-like protein 3
UniProt: Q8WTX7
Pockets: 15 · best druggability 0.63

Structure

x-ray diffraction · 4 distinct chains · 30% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gats-like protein 3	protein	277	30% helix, 34% strand	Q8WTX7
B	Gats-like protein 3	protein	270	30% helix, 36% strand	Q8WTX7
C	Gats-like protein 3	protein	268	31% helix, 34% strand	Q8WTX7
D	Gats-like protein 3	protein	265	27% helix, 36% strand	Q8WTX7

Pockets

15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	186	0.63	0.84	42	empty
2	423	0.60	0.76	55	empty
3	327	0.56	0.76	38	empty
4	300	0.55	0.75	45	empty
5	137	0.52	0.81	33	empty

Interfaces

4 interfaces between chains.

A–C · 920 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 418 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 149 Å² buried · 0 hydrogen bonds · protein-protein
C–D · 18 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5GT8 · Crystal Structure of apo-CASTOR1 · the same entry in another collection · chain D against D, TM-score 1.00
Q8WTX7 · AlphaFold monomer V2.0 prediction for cytosolic arginine sensor for MTORC1 subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WTX7
Elsewhere: RCSB PDB 5GT8 · PDBe 5GT8 · UniProt Q8WTX7

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