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Glycoside hydrolase a

Analyse Glycoside hydrolase a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5GSL
Type: protein
Length: 1,550 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 778AA long hypothetical beta-galactosidase
UniProt: O58247
Ligands: PO4
Pockets: 10 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	778AA long hypothetical beta-galactosidase	protein	775	29% helix, 27% strand	O58247

Ligands and binding sites

PO4 · Phosphate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	889	0.74	0.77	76	PO4
2	899	0.72	0.77	67	PO4
3	679	0.68	0.77	79	empty
4	177	0.62	0.84	29	empty
5	175	0.59	0.82	26	empty

Interfaces

1 interface between chains.

A–B · 3077 Å² buried · 63 hydrogen bonds · protein-protein

Compared structures

5GSL · Glycoside hydrolase A · the same entry in another collection · chain A against A, TM-score 1.00
O58247 · AlphaFold monomer V2.0 prediction for exo-beta-D-glucosaminidase (O58247) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O58247
Elsewhere: RCSB PDB 5GSL · PDBe 5GSL · UniProt O58247

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